diff --git a/Library/Homebrew/keg_relocate.rb b/Library/Homebrew/keg_relocate.rb
index a19eca11a2..772acd21b6 100644
--- a/Library/Homebrew/keg_relocate.rb
+++ b/Library/Homebrew/keg_relocate.rb
@@ -12,7 +12,7 @@ class Keg
   class Relocation
     extend T::Sig
 
-    RELOCATABLE_PATH_REGEX_PREFIX = /(?<![a-zA-Z0-9])/.freeze
+    RELOCATABLE_PATH_REGEX_PREFIX = /(?:(?<=-I|-L|-isystem)|(?<![a-zA-Z0-9]))/.freeze
 
     def initialize
       @replacement_map = {}