diff --git a/Library/Homebrew/extend/ENV/super.rb b/Library/Homebrew/extend/ENV/super.rb
index f46d88744a..977c30fd45 100644
--- a/Library/Homebrew/extend/ENV/super.rb
+++ b/Library/Homebrew/extend/ENV/super.rb
@@ -105,6 +105,8 @@ module Superenv
     #     have runtime detection of CPU features.
     # w - Pass -no_weak_imports to the linker
     # D - Generate debugging information
+    # f - Pass `-no_fixup_chains` to `ld` whenever it
+    #     is invoked with `-undefined dynamic_lookup`
     #
     # These flags will also be present:
     # a - apply fix for apr-1-config path
diff --git a/Library/Homebrew/extend/os/mac/extend/ENV/shared.rb b/Library/Homebrew/extend/os/mac/extend/ENV/shared.rb
index e2d47c2e76..a13761a8b3 100644
--- a/Library/Homebrew/extend/os/mac/extend/ENV/shared.rb
+++ b/Library/Homebrew/extend/os/mac/extend/ENV/shared.rb
@@ -23,4 +23,18 @@ module SharedEnvExtension
 
     true
   end
+
+  sig { returns(T::Boolean) }
+  def no_fixup_chains_support?
+    return false if MacOS.version <= :catalina
+
+    # NOTE: `-version_details` is supported in Xcode 10.2 at the earliest.
+    ld_version_details = JSON.parse(Utils.safe_popen_read("/usr/bin/ld", "-version_details"))
+    ld_version = Version.parse(ld_version_details["version"])
+
+    # This is supported starting Xcode 13, which ships ld64-711.
+    # https://developer.apple.com/documentation/xcode-release-notes/xcode-13-release-notes
+    # https://en.wikipedia.org/wiki/Xcode#Xcode_11.0_-_14.x_(since_SwiftUI_framework)_2
+    ld_version >= 711
+  end
 end
diff --git a/Library/Homebrew/extend/os/mac/extend/ENV/std.rb b/Library/Homebrew/extend/os/mac/extend/ENV/std.rb
index cb42b054a9..0312bfc5bd 100644
--- a/Library/Homebrew/extend/os/mac/extend/ENV/std.rb
+++ b/Library/Homebrew/extend/os/mac/extend/ENV/std.rb
@@ -101,4 +101,8 @@ module Stdenv
   def no_weak_imports
     append "LDFLAGS", "-Wl,-no_weak_imports" if no_weak_imports_support?
   end
+
+  def no_fixup_chains
+    append "LDFLAGS", "-Wl,-no_fixup_chains" if no_fixup_chains_support?
+  end
 end
diff --git a/Library/Homebrew/extend/os/mac/extend/ENV/super.rb b/Library/Homebrew/extend/os/mac/extend/ENV/super.rb
index bb032b370e..36aac56489 100644
--- a/Library/Homebrew/extend/os/mac/extend/ENV/super.rb
+++ b/Library/Homebrew/extend/os/mac/extend/ENV/super.rb
@@ -131,9 +131,18 @@ module Superenv
     # Notably, Xcode 10.2 fixes issues where ZERO_AR_DATE affected file mtimes.
     # Xcode 11.0 contains fixes for lldb reading things built with ZERO_AR_DATE.
     self["ZERO_AR_DATE"] = "1" if MacOS::Xcode.version >= "11.0" || MacOS::CLT.version >= "11.0"
+
+    # Pass `-no_fixup_chains` whenever the linker is invoked with `-undefined dynamic_lookup`.
+    # See: https://github.com/python/cpython/issues/97524
+    #      https://github.com/pybind/pybind11/pull/4301
+    no_fixup_chains
   end
 
   def no_weak_imports
     append_to_cccfg "w" if no_weak_imports_support?
   end
+
+  def no_fixup_chains
+    append_to_cccfg "f" if no_fixup_chains_support?
+  end
 end
diff --git a/Library/Homebrew/shims/super/cc b/Library/Homebrew/shims/super/cc
index 90b7f0e318..2706649680 100755
--- a/Library/Homebrew/shims/super/cc
+++ b/Library/Homebrew/shims/super/cc
@@ -221,7 +221,7 @@ class Cmd
       args << "-Wl,-undefined,dynamic_lookup"
     when /^-isysroot=/, /^--sysroot=/
       if mac?
-        sdk = arg.split("=")[1..-1].join("=")
+        sdk = arg.split("=", 2).last
         # We set the sysroot for macOS SDKs
         args << arg unless sdk.downcase.include? "osx"
       else
@@ -318,9 +318,11 @@ class Cmd
     when :ld
       args << "-headerpad_max_install_names"
       args << "-no_weak_imports" if no_weak_imports?
+      args << "-no_fixup_chains" if no_fixup_chains?
     when :ccld, :cxxld
       args << "-Wl,-headerpad_max_install_names"
       args << "-Wl,-no_weak_imports" if no_weak_imports?
+      args << "-Wl,-no_fixup_chains" if no_fixup_chains?
     end
     args
   end
@@ -416,6 +418,32 @@ class Cmd
     config.include?("D")
   end
 
+  def no_fixup_chains?
+    return false unless config.include?("f")
+    return false unless calls_ld?
+    return true if @args.include?("-Wl,-undefined,dynamic_lookup")
+
+    args_consecutive_pairs = @args.each_cons(2)
+    return true if args_consecutive_pairs.include?(["-undefined", "dynamic_lookup"])
+    return true if args_consecutive_pairs.include?(["-Wl,-undefined", "-Wl,dynamic_lookup"])
+
+    # The next flag would produce an error, but we fix it in `refurbish_arg`.
+    @args.include?("-undefineddynamic_lookup")
+  end
+
+  def calls_ld?
+    return true if mode == :ld
+    return false unless [:ccld, :cxxld].include?(mode)
+
+    fuse_ld_flags = @args.find_all { |arg| arg.match?(/^-fuse-ld=/) }
+    return true if fuse_ld_flags.empty?
+
+    fuse_ld_flag = fuse_ld_flags.last.strip
+    fuse_ld_arg = fuse_ld_flag.split("=", 2).last
+
+    (fuse_ld_arg == "ld") || fuse_ld_arg.end_with?("/usr/bin/ld")
+  end
+
   def canonical_path(path)
     path = Pathname.new(path)
     path = path.realpath if path.exist?