diff --git a/Library/Homebrew/keg_relocate.rb b/Library/Homebrew/keg_relocate.rb
index 46170cd448..d023d10209 100644
--- a/Library/Homebrew/keg_relocate.rb
+++ b/Library/Homebrew/keg_relocate.rb
@@ -96,7 +96,7 @@ class Keg
     end
     relocation.add_replacement_pair(:library, HOMEBREW_LIBRARY.to_s, LIBRARY_PLACEHOLDER, path: true)
     relocation.add_replacement_pair(:perl,
-                                    %r{\A#!(?:/usr/bin/perl\d\.\d+|#{HOMEBREW_PREFIX}/opt/perl/bin/perl)( |$)}o,
+                                    %r{\A#![ \t]*(?:/usr/bin/perl\d\.\d+|#{HOMEBREW_PREFIX}/opt/perl/bin/perl)( |$)}o,
                                     "#!#{PERL_PLACEHOLDER}\\1")
     relocation.add_replacement_pair(:java, JAVA_REGEX, JAVA_PLACEHOLDER)