diff --git a/Library/Homebrew/extend/os/mac/keg_relocate.rb b/Library/Homebrew/extend/os/mac/keg_relocate.rb
index 86dc1258e8..50a65f4d78 100644
--- a/Library/Homebrew/extend/os/mac/keg_relocate.rb
+++ b/Library/Homebrew/extend/os/mac/keg_relocate.rb
@@ -35,6 +35,18 @@ class Keg
 
           change_install_name(old_name, new_name, file) if new_name
         end
+
+        if ENV["HOMEBREW_RELOCATE_RPATHS"]
+          each_rpath_for(file) do |old_name|
+            new_name = if old_name.start_with? relocation.old_cellar
+              old_name.sub(relocation.old_cellar, relocation.new_cellar)
+            elsif old_name.start_with? relocation.old_prefix
+              old_name.sub(relocation.old_prefix, relocation.new_prefix)
+            end
+
+            change_rpath(old_name, new_name, file) if new_name
+          end
+        end
       end
     end
   end
@@ -111,6 +123,12 @@ class Keg
     dylibs.each(&block)
   end
 
+  def each_rpath_for(file, &block)
+    rpaths = file.rpaths
+                 .reject { |fn| fn =~ /^@(loader|executable)_path/ }
+    rpaths.each(&block)
+  end
+
   def dylib_id_for(file)
     # The new dylib ID should have the same basename as the old dylib ID, not
     # the basename of the file itself.
diff --git a/Library/Homebrew/os/mac/keg.rb b/Library/Homebrew/os/mac/keg.rb
index 901c4dc7ee..72a3b85908 100644
--- a/Library/Homebrew/os/mac/keg.rb
+++ b/Library/Homebrew/os/mac/keg.rb
@@ -34,6 +34,22 @@ class Keg
     raise
   end
 
+  def change_rpath(old, new, file)
+    return if old == new
+
+    @require_relocation = true
+    odebug "Changing rpath in #{file}\n  from #{old}\n    to #{new}"
+    MachO::Tools.change_rpath(file, old, new, strict: false)
+    apply_ad_hoc_signature(file)
+  rescue MachO::MachOError
+    onoe <<~EOS
+      Failed changing rpath in #{file}
+        from #{old}
+          to #{new}
+    EOS
+    raise
+  end
+
   def apply_ad_hoc_signature(file)
     return if MacOS.version < :big_sur
     return unless Hardware::CPU.arm?