diff --git a/Library/Homebrew/cli/args.rbi b/Library/Homebrew/cli/args.rbi
index c7746169fe..3dbdf28fb8 100644
--- a/Library/Homebrew/cli/args.rbi
+++ b/Library/Homebrew/cli/args.rbi
@@ -168,7 +168,7 @@ module Homebrew
       sig { returns(T.nilable(String)) }
       def tap; end
 
-      sig { returns(T.nilable(String)) }
+      sig { returns(T.nilable(T::Array[String])) }
       def macos; end
 
       sig { returns(T.nilable(T::Array[String])) }
diff --git a/Library/Homebrew/dev-cmd/dispatch-build-bottle.rb b/Library/Homebrew/dev-cmd/dispatch-build-bottle.rb
index 5c1a19bf00..8ef5c43ad4 100644
--- a/Library/Homebrew/dev-cmd/dispatch-build-bottle.rb
+++ b/Library/Homebrew/dev-cmd/dispatch-build-bottle.rb
@@ -21,8 +21,8 @@ module Homebrew
              description: "Build timeout (in minutes, default: 60)."
       flag   "--issue=",
              description: "If specified, post a comment to this issue number if the job fails."
-      flag   "--macos=",
-             description: "Version of macOS the bottle should be built for."
+      comma_array "--macos=",
+                  description: "Version(s) of macOS the bottle should be built for."
       flag   "--workflow=",
              description: "Dispatch specified workflow (default: `dispatch-build-bottle.yml`)."
       switch "--upload",
@@ -51,25 +51,27 @@ module Homebrew
     # TODO: remove when core taps are merged
     repo.gsub!("linux", "home") unless args.tap
 
-    runner = if (macos = args.macos)
-      # We accept runner name syntax (11-arm64) or bottle syntax (arm64_big_sur)
-      os, arch = macos.yield_self do |s|
-        tag = Utils::Bottles::Tag.from_symbol(s.to_sym)
-        [tag.to_macos_version, tag.arch]
-      rescue ArgumentError, MacOSVersionError
-        os, arch = s.split("-", 2)
-        [MacOS::Version.new(os), arch&.to_sym]
-      end
+    runners = if (macos = args.macos&.compact_blank) && macos.present?
+      macos.map do |element|
+        # We accept runner name syntax (11-arm64) or bottle syntax (arm64_big_sur)
+        os, arch = element.yield_self do |s|
+          tag = Utils::Bottles::Tag.from_symbol(s.to_sym)
+          [tag.to_macos_version, tag.arch]
+        rescue ArgumentError, MacOSVersionError
+          os, arch = s.split("-", 2)
+          [MacOS::Version.new(os), arch&.to_sym]
+        end
 
-      if arch.present? && arch != :x86_64
-        "#{os}-#{arch}"
-      else
-        os.to_s
+        if arch.present? && arch != :x86_64
+          "#{os}-#{arch}"
+        else
+          os.to_s
+        end
       end
     elsif args.linux?
-      "ubuntu-latest"
+      ["ubuntu-latest"]
     elsif args.linux_self_hosted?
-      "linux-self-hosted-1"
+      ["linux-self-hosted-1"]
     else
       raise UsageError, "Must specify --macos or --linux or --linux-self-hosted option"
     end
@@ -77,7 +79,7 @@ module Homebrew
     args.named.to_resolved_formulae.each do |formula|
       # Required inputs
       inputs = {
-        runner:  runner,
+        runner:  runners.join(","),
         formula: formula.name,
       }
 
@@ -88,7 +90,7 @@ module Homebrew
       inputs[:upload] = args.upload?.to_s if args.upload?
       inputs[:wheezy] = args.linux_wheezy?.to_s if args.linux_wheezy?
 
-      ohai "Dispatching #{tap} bottling request of formula \"#{formula.name}\" for #{runner}"
+      ohai "Dispatching #{tap} bottling request of formula \"#{formula.name}\" for #{runners.join(", ")}"
       GitHub.workflow_dispatch_event(user, repo, workflow, ref, inputs)
     end
   end