diff --git a/Library/Homebrew/dev-cmd/pr-publish.rb b/Library/Homebrew/dev-cmd/pr-publish.rb
index da152254ce..c1220ee941 100644
--- a/Library/Homebrew/dev-cmd/pr-publish.rb
+++ b/Library/Homebrew/dev-cmd/pr-publish.rb
@@ -64,6 +64,10 @@ module Homebrew
         oh1 "Found `autosquash` label on ##{issue}. Requesting autosquash."
         inputs[:autosquash] = true
       end
+      if pr_labels.include?("large-bottle-upload")
+        oh1 "Found `large-bottle-upload` label on ##{issue}. Requesting upload on large runner."
+        inputs[:large_runner] = true
+      end
 
       if args.tap.present? && !T.must("#{user}/#{repo}".casecmp(tap.full_name)).zero?
         odie "Pull request URL is for #{user}/#{repo} but `--tap=#{tap.full_name}` was specified!"