diff --git a/Library/Homebrew/install.rb b/Library/Homebrew/install.rb
index 155a480996..abb931c980 100644
--- a/Library/Homebrew/install.rb
+++ b/Library/Homebrew/install.rb
@@ -30,8 +30,14 @@ module Homebrew
     end
 
     def check_prefix
-      if Hardware::CPU.intel? && HOMEBREW_PREFIX.to_s == HOMEBREW_MACOS_ARM_DEFAULT_PREFIX
-        odie "Cannot install in Homebrew on Intel processor in ARM default prefix (#{HOMEBREW_PREFIX})!"
+      if (Hardware::CPU.intel? || Hardware::CPU.in_rosetta2?) &&
+         HOMEBREW_PREFIX.to_s == HOMEBREW_MACOS_ARM_DEFAULT_PREFIX
+        configuration = if Hardware::CPU.in_rosetta2?
+          "on Intel processor"
+        else
+          "under Rosetta 2"
+        end
+        odie "Cannot install in Homebrew #{configuration} in ARM default prefix (#{HOMEBREW_PREFIX})!"
       elsif Hardware::CPU.arm? && HOMEBREW_PREFIX.to_s == HOMEBREW_DEFAULT_PREFIX
         odie <<~EOS
           Cannot install in Homebrew on ARM processor in Intel default prefix (#{HOMEBREW_PREFIX})!