diff --git a/Library/Homebrew/extend/os/mac/keg_relocate.rb b/Library/Homebrew/extend/os/mac/keg_relocate.rb
index 77c8a4ca31..5139d2494a 100644
--- a/Library/Homebrew/extend/os/mac/keg_relocate.rb
+++ b/Library/Homebrew/extend/os/mac/keg_relocate.rb
@@ -69,12 +69,32 @@ class Keg
           new_name = fixed_name(file, bad_name)
           change_install_name(bad_name, new_name, file) unless new_name == bad_name
         end
+
+        # If none of the install names reference RPATH(s), then we can safely
+        # remove all RPATHs from the file.
+        if file.dynamically_linked_libraries.none? { |lib| lib.start_with?("@rpath") }
+          # Note: This could probably be made more efficient by reverse-sorting
+          # the RPATHs by offset and calling MachOFile#delete_command
+          # with repopulate: false.
+          file.rpaths.each { |r| file.delete_rpath(r) }
+        end
       end
     end
 
     generic_fix_dynamic_linkage
   end
 
+  def expand_rpath(file, bad_name)
+    suffix = bad_name.sub(/^@rpath/, "")
+
+    file.rpaths.each do |rpath|
+      return rpath/suffix if (rpath/suffix).exist?
+    end
+
+    opoo "Could not find library #{bad_name} for #{file}"
+    bad_name
+  end
+
   # If file is a dylib or bundle itself, look for the dylib named by
   # bad_name relative to the lib directory, so that we can skip the more
   # expensive recursive search if possible.
@@ -87,6 +107,8 @@ class Keg
       "@loader_path/#{bad_name}"
     elsif file.mach_o_executable? && (lib + bad_name).exist?
       "#{lib}/#{bad_name}"
+    elsif bad_name.start_with?("@rpath") && ENV["HOMEBREW_RELOCATE_METAVARS"]
+      expand_rpath file, bad_name
     elsif (abs_name = find_dylib(bad_name)) && abs_name.exist?
       abs_name.to_s
     else
@@ -97,7 +119,7 @@ class Keg
 
   def each_install_name_for(file, &block)
     dylibs = file.dynamically_linked_libraries
-    dylibs.reject! { |fn| fn =~ /^@(loader_|executable_|r)path/ }
+    dylibs.reject! { |fn| fn =~ /^@(loader|executable)_path/ }
     dylibs.each(&block)
   end
 
diff --git a/Library/Homebrew/os/mac/mach.rb b/Library/Homebrew/os/mac/mach.rb
index 49e49cd702..4e7c86e98f 100644
--- a/Library/Homebrew/os/mac/mach.rb
+++ b/Library/Homebrew/os/mac/mach.rb
@@ -2,6 +2,10 @@ require "macho"
 require "os/mac/architecture_list"
 
 module MachOShim
+  extend Forwardable
+
+  delegate [:dylib_id, :rpaths, :delete_rpath] => :macho
+
   # @private
   def macho
     @macho ||= begin
@@ -56,10 +60,6 @@ module MachOShim
     lcs.map(&:name).map(&:to_s).uniq
   end
 
-  def dylib_id
-    macho.dylib_id
-  end
-
   def archs
     mach_data.map { |m| m.fetch :arch }.extend(ArchitectureListExtension)
   end