diff --git a/Library/Homebrew/resource_auditor.rb b/Library/Homebrew/resource_auditor.rb
index 796af321e5..6e28607a41 100644
--- a/Library/Homebrew/resource_auditor.rb
+++ b/Library/Homebrew/resource_auditor.rb
@@ -108,8 +108,16 @@ module Homebrew
       return unless url.match?(%r{^https?://files\.pythonhosted\.org/packages/})
       return if name == owner.name # Skip the top-level package name as we only care about `resource "foo"` blocks.
 
-      url =~ %r{/(?<package_name>[^/]+)-}
-      pypi_package_name = Regexp.last_match(:package_name).to_s.gsub(/[_.]/, "-")
+      if url.end_with? ".whl"
+        path = URI(url).path
+        return unless path.present?
+
+        pypi_package_name, = File.basename(path).split("-", 2)
+      else
+        url =~ %r{/(?<package_name>[^/]+)-}
+        pypi_package_name = Regexp.last_match(:package_name).to_s.gsub(/[_.]/, "-")
+      end
+
       return if name.casecmp(pypi_package_name).zero?
 
       problem "resource name should be `#{pypi_package_name}` to match the PyPI package name"
diff --git a/Library/Homebrew/test/formula_auditor_spec.rb b/Library/Homebrew/test/formula_auditor_spec.rb
index cb52b57c58..8417849849 100644
--- a/Library/Homebrew/test/formula_auditor_spec.rb
+++ b/Library/Homebrew/test/formula_auditor_spec.rb
@@ -503,7 +503,7 @@ RSpec.describe Homebrew::FormulaAuditor do
   end
 
   describe "#audit_resource_name_matches_pypi_package_name_in_url" do
-    it "reports a problem if the resource name does not match the python package name" do
+    it "reports a problem if the resource name does not match the python sdist name" do
       fa = formula_auditor "foo", <<~RUBY
         class Foo < Formula
           url "https://brew.sh/foo-1.0.tgz"
@@ -521,6 +521,25 @@ RSpec.describe Homebrew::FormulaAuditor do
       expect(fa.problems.first[:message])
         .to match("resource name should be `FooSomething` to match the PyPI package name")
     end
+
+    it "reports a problem if the resource name does not match the python wheel name" do
+      fa = formula_auditor "foo", <<~RUBY
+        class Foo < Formula
+          url "https://brew.sh/foo-1.0.tgz"
+          sha256 "abc123"
+          homepage "https://brew.sh"
+
+          resource "Something" do
+            url "https://files.pythonhosted.org/packages/FooSomething-1.0.0-py3-none-any.whl"
+            sha256 "def456"
+          end
+        end
+      RUBY
+
+      fa.audit_specs
+      expect(fa.problems.first[:message])
+        .to match("resource name should be `FooSomething` to match the PyPI package name")
+    end
   end
 
   describe "#check_service_command" do
diff --git a/Library/Homebrew/utils/pypi.rb b/Library/Homebrew/utils/pypi.rb
index db9f6337e7..59fb275b5f 100644
--- a/Library/Homebrew/utils/pypi.rb
+++ b/Library/Homebrew/utils/pypi.rb
@@ -73,12 +73,22 @@ module PyPI
         return
       end
 
-      sdist = json["urls"].find { |url| url["packagetype"] == "sdist" }
-      return if sdist.nil?
+      dist = json["urls"].find do |url|
+        url["packagetype"] == "sdist"
+      end
+
+      # If there isn't an sdist, we use the first universal wheel.
+      if dist.nil?
+        dist = json["urls"].find do |url|
+          url["filename"].end_with?("-none-any.whl")
+        end
+      end
+
+      return if dist.nil?
 
       @pypi_info = [
-        PyPI.normalize_python_package(json["info"]["name"]), sdist["url"],
-        sdist["digests"]["sha256"], json["info"]["version"]
+        PyPI.normalize_python_package(json["info"]["name"]), dist["url"],
+        dist["digests"]["sha256"], json["info"]["version"]
       ]
     end