diff --git a/Library/Homebrew/dev-cmd/pr-upload.rb b/Library/Homebrew/dev-cmd/pr-upload.rb
index 03c2512ca4..9a4846e35d 100644
--- a/Library/Homebrew/dev-cmd/pr-upload.rb
+++ b/Library/Homebrew/dev-cmd/pr-upload.rb
@@ -4,6 +4,7 @@
 require "cli/parser"
 require "archive"
 require "bintray"
+require "github_packages"
 require "github_releases"
 
 module Homebrew
@@ -33,6 +34,8 @@ module Homebrew
              description: "Upload to the specified Internet Archive item (default: `homebrew`)."
       flag   "--bintray-org=",
              description: "Upload to the specified Bintray organisation (default: `homebrew`)."
+      flag   "--github-org=",
+             description: "Upload to the specified GitHub organisation's GitHub Packages (default: `homebrew`)."
       flag   "--root-url=",
              description: "Use the specified <URL> as the root of the bottle's URL instead of Homebrew's default."
 
@@ -73,6 +76,12 @@ module Homebrew
     end
   end
 
+  def github_packages?(bottles_hash)
+    @github_packages ||= bottles_hash.values.all? do |bottle_hash|
+      bottle_hash["bottle"]["root_url"].match? GitHubPackages::URL_REGEX
+    end
+  end
+
   def pr_upload
     args = pr_upload_args.parse
 
@@ -99,6 +108,8 @@ module Homebrew
           "Bintray"
         elsif github_releases?(bottles_hash)
           "GitHub Releases"
+        elsif github_packages?(bottles_hash)
+          "GitHub Packages"
         else
           odie "Service specified by root_url is not recognized"
         end
@@ -137,6 +148,10 @@ module Homebrew
     elsif github_releases?(bottles_hash)
       github_releases = GitHubReleases.new
       github_releases.upload_bottles(bottles_hash)
+    elsif github_packages?(bottles_hash)
+      github_org = args.github_org || "homebrew"
+      github_packages = GitHubPackages.new(org: github_org)
+      github_packages.upload_bottles(bottles_hash)
     else
       odie "Service specified by root_url is not recognized"
     end
diff --git a/Library/Homebrew/env_config.rb b/Library/Homebrew/env_config.rb
index 391d7e38c9..cd8ff0a1a5 100644
--- a/Library/Homebrew/env_config.rb
+++ b/Library/Homebrew/env_config.rb
@@ -172,6 +172,13 @@ module Homebrew
                      "\n\n    *Note:* Homebrew doesn't require permissions for any of the scopes, but some " \
                      "developer commands may require additional permissions.",
       },
+      HOMEBREW_GITHUB_PACKAGES_TOKEN:         {
+        description: "Use this GitHub personal access token when accessing the GitHub Packages Registry "\
+                     "(where bottles may be stored).",
+      },
+      HOMEBREW_GITHUB_PACKAGES_USER:          {
+        description: "Use this username when accessing the GitHub Packages Registry (where bottles may be stored).",
+      },
       HOMEBREW_GIT_EMAIL:                     {
         description: "Set the Git author and committer email to this value.",
       },
diff --git a/Library/Homebrew/github_packages.rb b/Library/Homebrew/github_packages.rb
new file mode 100644
index 0000000000..daaad08bba
--- /dev/null
+++ b/Library/Homebrew/github_packages.rb
@@ -0,0 +1,71 @@
+# typed: false
+# frozen_string_literal: true
+
+require "utils/curl"
+require "json"
+
+# GitHub Packages client.
+#
+# @api private
+class GitHubPackages
+  extend T::Sig
+
+  include Context
+  include Utils::Curl
+
+  URL_REGEX = %r{https://ghcr.io/v2/([\w-]+)/([\w-]+)}.freeze
+
+  sig { returns(String) }
+  def inspect
+    "#<GitHubPackages: org=#{@github_org}>"
+  end
+
+  sig { params(org: T.nilable(String)).void }
+  def initialize(org: "homebrew")
+    @github_org = org
+
+    raise UsageError, "Must set a GitHub organisation!" unless @github_org
+
+    ENV["HOMEBREW_FORCE_HOMEBREW_ON_LINUX"] = "1" if @github_org == "homebrew" && !OS.mac?
+  end
+
+  sig { params(bottles_hash: T::Hash[String, T.untyped]).void }
+  def upload_bottles(bottles_hash)
+    user = Homebrew::EnvConfig.github_packages_user
+    token = Homebrew::EnvConfig.github_packages_token
+
+    raise UsageError, "HOMEBREW_GITHUB_PACKAGES_USER is unset." if user.blank?
+    raise UsageError, "HOMEBREW_GITHUB_PACKAGES_TOKEN is unset." if token.blank?
+
+    oras   = Formula["oras"].opt_bin/"oras" if Formula["oras"].any_version_installed?
+    oras ||= begin
+      ohai "Installing `oras` for upload..."
+      safe_system HOMEBREW_BREW_FILE, "install", "oras"
+      Formula["oras"].opt_bin/"oras"
+    end
+
+    bottles_hash.each do |formula_name, bottle_hash|
+      _, org, repo, = *bottle_hash["bottle"]["root_url"].match(URL_REGEX)
+      version = bottle_hash["formula"]["pkg_version"]
+      rebuild = bottle_hash["bottle"]["rebuild"]
+
+      bottle_hash["bottle"]["tags"].each do |bottle_tag, tag_hash|
+        local_file = tag_hash["local_filename"]
+        odebug "Uploading #{local_file}"
+
+        tag = "#{version}.#{bottle_tag}"
+        tag = "#{tag}.#{rebuild}" if rebuild.positive?
+
+        system_command!(oras, verbose: true, print_stdout: true, args: [
+          "push", "ghcr.io/#{org}/#{repo}/#{formula_name}:#{tag}",
+          "--username", user,
+          "--password", token,
+          "#{local_file}:application/vnd.oci.image.layer.v1.tar+gzip"
+        ])
+
+        # TODO: make this package public?
+        # TODO: make this latest?
+      end
+    end
+  end
+end
diff --git a/completions/bash/brew b/completions/bash/brew
index c08a2f4f01..e9aa2d4cfb 100644
--- a/completions/bash/brew
+++ b/completions/bash/brew
@@ -1483,6 +1483,7 @@ _brew_pr_upload() {
       --bintray-org
       --debug
       --dry-run
+      --github-org
       --help
       --keep-old
       --no-commit
diff --git a/completions/fish/brew.fish b/completions/fish/brew.fish
index 827d0e60e6..842c424a88 100644
--- a/completions/fish/brew.fish
+++ b/completions/fish/brew.fish
@@ -1069,6 +1069,7 @@ __fish_brew_complete_arg 'pr-upload' -l archive-item -d 'Upload to the specified
 __fish_brew_complete_arg 'pr-upload' -l bintray-org -d 'Upload to the specified Bintray organisation (default: `homebrew`)'
 __fish_brew_complete_arg 'pr-upload' -l debug -d 'Display any debugging information'
 __fish_brew_complete_arg 'pr-upload' -l dry-run -d 'Print what would be done rather than doing it'
+__fish_brew_complete_arg 'pr-upload' -l github-org -d 'Upload to the specified GitHub organisation\'s GitHub Packages (default: `homebrew`)'
 __fish_brew_complete_arg 'pr-upload' -l help -d 'Show this message'
 __fish_brew_complete_arg 'pr-upload' -l keep-old -d 'If the formula specifies a rebuild version, attempt to preserve its value in the generated DSL'
 __fish_brew_complete_arg 'pr-upload' -l no-commit -d 'Do not generate a new commit before uploading'
diff --git a/completions/zsh/_brew b/completions/zsh/_brew
index bffa4d86a6..8142d84e7b 100644
--- a/completions/zsh/_brew
+++ b/completions/zsh/_brew
@@ -1243,6 +1243,7 @@ _brew_pr_upload() {
     '--bintray-org[Upload to the specified Bintray organisation (default: `homebrew`)]' \
     '--debug[Display any debugging information]' \
     '--dry-run[Print what would be done rather than doing it]' \
+    '--github-org[Upload to the specified GitHub organisation'\''s GitHub Packages (default: `homebrew`)]' \
     '--help[Show this message]' \
     '--keep-old[If the formula specifies a rebuild version, attempt to preserve its value in the generated DSL]' \
     '--no-commit[Do not generate a new commit before uploading]' \
diff --git a/docs/Manpage.md b/docs/Manpage.md
index 507b314185..627cc6e371 100644
--- a/docs/Manpage.md
+++ b/docs/Manpage.md
@@ -1214,6 +1214,8 @@ Apply the bottle commit and publish bottles to a host.
   Upload to the specified Internet Archive item (default: `homebrew`).
 * `--bintray-org`:
   Upload to the specified Bintray organisation (default: `homebrew`).
+* `--github-org`:
+  Upload to the specified GitHub organisation's GitHub Packages (default: `homebrew`).
 * `--root-url`:
   Use the specified *`URL`* as the root of the bottle's URL instead of Homebrew's default.
 
@@ -1829,6 +1831,12 @@ example, run `export HOMEBREW_NO_INSECURE_REDIRECT=1` rather than just
 
     *Note:* Homebrew doesn't require permissions for any of the scopes, but some developer commands may require additional permissions.
 
+- `HOMEBREW_GITHUB_PACKAGES_TOKEN`
+  <br>Use this GitHub personal access token when accessing the GitHub Packages Registry (where bottles may be stored).
+
+- `HOMEBREW_GITHUB_PACKAGES_USER`
+  <br>Use this username when accessing the GitHub Packages Registry (where bottles may be stored).
+
 - `HOMEBREW_GIT_EMAIL`
   <br>Set the Git author and committer email to this value.
 
diff --git a/manpages/brew.1 b/manpages/brew.1
index d218cd8c79..827c8e5721 100644
--- a/manpages/brew.1
+++ b/manpages/brew.1
@@ -1708,6 +1708,10 @@ Upload to the specified Internet Archive item (default: \fBhomebrew\fR)\.
 Upload to the specified Bintray organisation (default: \fBhomebrew\fR)\.
 .
 .TP
+\fB\-\-github\-org\fR
+Upload to the specified GitHub organisation\'s GitHub Packages (default: \fBhomebrew\fR)\.
+.
+.TP
 \fB\-\-root\-url\fR
 Use the specified \fIURL\fR as the root of the bottle\'s URL instead of Homebrew\'s default\.
 .
@@ -2602,6 +2606,18 @@ Use this personal access token for the GitHub API, for features such as \fBbrew
 \fINote:\fR Homebrew doesn\'t require permissions for any of the scopes, but some developer commands may require additional permissions\.
 .
 .TP
+\fBHOMEBREW_GITHUB_PACKAGES_TOKEN\fR
+.
+.br
+Use this GitHub personal access token when accessing the GitHub Packages Registry (where bottles may be stored)\.
+.
+.TP
+\fBHOMEBREW_GITHUB_PACKAGES_USER\fR
+.
+.br
+Use this username when accessing the GitHub Packages Registry (where bottles may be stored)\.
+.
+.TP
 \fBHOMEBREW_GIT_EMAIL\fR
 .
 .br