diff --git a/Library/Homebrew/extend/ENV/super.rb b/Library/Homebrew/extend/ENV/super.rb
index 17334a3a24..e2ce2e6262 100644
--- a/Library/Homebrew/extend/ENV/super.rb
+++ b/Library/Homebrew/extend/ENV/super.rb
@@ -91,10 +91,11 @@ module Superenv
     # g - Enable "-stdlib=libc++" for clang.
     # h - Enable "-stdlib=libstdc++" for clang.
     # K - Don't strip -arch <arch>, -m32, or -m64
+    # d - Don't strip -march=<target>. Use only in formulae that
+    #     have runtime detection of CPU features.
     # w - Pass -no_weak_imports to the linker
     #
     # These flags will also be present:
-    # s - apply fix for sed's Unicode support
     # a - apply fix for apr-1-config path
   end
   alias generic_setup_build_environment setup_build_environment
@@ -314,6 +315,11 @@ module Superenv
     append_to_cccfg "K"
   end
 
+  sig { void }
+  def runtime_cpu_detection
+    append_to_cccfg "d"
+  end
+
   sig { void }
   def cxx11
     append_to_cccfg "x"
diff --git a/Library/Homebrew/shims/super/cc b/Library/Homebrew/shims/super/cc
index b1cc61e274..fbe556f8b0 100755
--- a/Library/Homebrew/shims/super/cc
+++ b/Library/Homebrew/shims/super/cc
@@ -173,10 +173,12 @@ class Cmd
 
     case arg
     when /^-g\d?$/, /^-gstabs\d+/, "-gstabs+", /^-ggdb\d?/,
-      /^-march=.+/, /^-mtune=.+/, /^-mcpu=.+/,
-      /^-O[0-9zs]?$/, "-fast", "-no-cpp-precomp",
-      "-pedantic", "-pedantic-errors", "-Wno-long-double",
+      /^-mtune=.+/, /^-mcpu=.+/, /^-O[0-9zs]?$/,
+      "-fast", "-no-cpp-precomp", "-pedantic",
+      "-pedantic-errors", "-Wno-long-double",
       "-Wno-unused-but-set-variable"
+    when /^-march=.+/
+      args << arg if runtime_cpu_detection?
     when "-fopenmp", "-lgomp", "-mno-fused-madd", "-fforce-addr", "-fno-defer-pop",
       "-mno-dynamic-no-pic", "-fearly-inlining", /^-f(?:no-)?inline-functions-called-once/,
       /^-finline-limit/, /^-f(?:no-)?check-new/, "-fno-delete-null-pointer-checks",
@@ -283,7 +285,7 @@ class Cmd
     args << "-pipe"
     args << "-w" unless configure?
     args << "-#{ENV["HOMEBREW_OPTIMIZATION_LEVEL"]}"
-    args.concat(optflags)
+    args.concat(optflags) unless runtime_cpu_detection?
     args.concat(archflags)
     args << "-std=#{@arg0}" if /c[89]9/.match?(@arg0)
     args
@@ -385,6 +387,10 @@ class Cmd
     config.include?("K")
   end
 
+  def runtime_cpu_detection?
+    config.include?("d")
+  end
+
   def no_weak_imports?
     config.include?("w")
   end