diff --git a/Library/Homebrew/cask/audit.rb b/Library/Homebrew/cask/audit.rb
index e27a04ca0f..3d8feb3c54 100644
--- a/Library/Homebrew/cask/audit.rb
+++ b/Library/Homebrew/cask/audit.rb
@@ -4,6 +4,7 @@
 require "cask/denylist"
 require "cask/download"
 require "cask/installer"
+require "cask/quarantine"
 require "digest"
 require "livecheck/livecheck"
 require "source_location"
@@ -501,6 +502,11 @@ module Cask
       return if !cask.tap.official? && !signing?
       return if cask.deprecated? && cask.deprecation_reason != :unsigned
 
+      unless Quarantine.available?
+        odebug "Quarantine support is not available, skipping signing audit"
+        return
+      end
+
       odebug "Auditing signing"
 
       is_in_skiplist = cask.tap&.audit_exception(:signing_audit_skiplist, cask.token)
@@ -515,6 +521,11 @@ module Cask
 
           path = tmpdir/artifact_path.relative_path_from(cask.staged_path)
 
+          unless Quarantine.detect(path)
+            odebug "#{path} does not have quarantine attributes, skipping signing audit"
+            next false
+          end
+
           result = case artifact
           when Artifact::Pkg
             system_command("spctl", args: ["--assess", "--type", "install", path], print_stderr: false)
diff --git a/Library/Homebrew/test/cask/audit_spec.rb b/Library/Homebrew/test/cask/audit_spec.rb
index 04f52dc4de..7ee1cf489c 100644
--- a/Library/Homebrew/test/cask/audit_spec.rb
+++ b/Library/Homebrew/test/cask/audit_spec.rb
@@ -453,6 +453,7 @@ RSpec.describe Cask::Audit, :cask do
 
     describe "signing checks" do
       let(:only) { ["signing"] }
+      let(:tap) { CoreCaskTap.instance }
       let(:download_double) { instance_double(Cask::Download) }
       let(:unpack_double) { instance_double(UnpackStrategy::Zip) }
 
@@ -495,6 +496,31 @@ RSpec.describe Cask::Audit, :cask do
           expect(run).not_to error_with(/Audit\.app/)
         end
       end
+
+      context "when quarantine support is not available" do
+        let(:cask) do
+          tmp_cask "signing-cask-test", <<~RUBY
+            cask 'signing-cask-test' do
+              version '1.0'
+              url "https://brew.sh/"
+              app 'Audit.app'
+            end
+          RUBY
+        end
+
+        before do
+          allow(cask).to receive(:tap).and_return(tap)
+
+          allow(Cask::Quarantine).to receive(:available?).and_return(false)
+        end
+
+        it "skips signing audit with warning" do
+          allow(cask).to receive(:tap).and_return(tap)
+
+          expect(audit).to receive(:odebug).with("Quarantine support is not available, skipping signing audit")
+          expect(run).not_to error_with(/Signature verification failed/)
+        end
+      end
     end
 
     describe "livecheck should be skipped", :no_api do