diff --git a/Library/Homebrew/cmd/autoremove.rb b/Library/Homebrew/cmd/autoremove.rb
index e001c42edb..223614bc0a 100644
--- a/Library/Homebrew/cmd/autoremove.rb
+++ b/Library/Homebrew/cmd/autoremove.rb
@@ -36,6 +36,10 @@ module Homebrew
     removable_formulae = get_removable_formulae(Formula.installed)
     return if removable_formulae.blank?
 
+    if Cask::Caskroom.casks.present?
+      removable_formulae -= Cask::Caskroom.casks.flat_map { |cask| cask.depends_on[:formula] }
+                                          .compact.map { |formula| Formula[formula] }
+    end
     formulae_names = removable_formulae.map(&:full_name).sort
 
     verb = args.dry_run? ? "Would uninstall" : "Uninstalling"