diff --git a/Library/Homebrew/utils/pypi.rb b/Library/Homebrew/utils/pypi.rb
index e24fefe09e..38d7e75ea0 100644
--- a/Library/Homebrew/utils/pypi.rb
+++ b/Library/Homebrew/utils/pypi.rb
@@ -250,7 +250,7 @@ module PyPI
 
     extra_packages = (extra_packages || []).map { |p| Package.new p }
     exclude_packages = (exclude_packages || []).map { |p| Package.new p }
-    exclude_packages += %W[#{main_package.name} argparse pip setuptools wsgiref].map { |p| Package.new p }
+    exclude_packages += %w[argparse pip setuptools wsgiref].map { |p| Package.new p }
     # remove packages from the exclude list if we've explicitly requested them as an extra package
     exclude_packages.delete_if { |package| extra_packages.include?(package) }
 
@@ -278,20 +278,13 @@ module PyPI
 
     ensure_formula_installed!("python")
 
+    # Resolve the dependency tree of all input packages
     ohai "Retrieving PyPI dependencies for \"#{input_packages.join(" ")}\"..." if !print_only && !silent
-    command =
-      [Formula["python"].bin/"python3", "-m", "pip", "install", "-q", "--dry-run", "--ignore-installed", "--report",
-       "/dev/stdout", *input_packages.map(&:to_s)]
-    pip_output = Utils.popen_read({ "PIP_REQUIRE_VIRTUALENV" => "false" }, *command)
-    unless $CHILD_STATUS.success?
-      odie <<~EOS
-        Unable to determine dependencies for "#{input_packages.join(" ")}" because of a failure when running
-        `#{command.join(" ")}`.
-        Please update the resources for "#{formula.name}" manually.
-      EOS
-    end
-
-    found_packages = pip_report_to_packages(JSON.parse(pip_output), exclude_packages).uniq
+    found_packages = pip_report(input_packages)
+    # Resolve the dependency tree of excluded packages to prune the above
+    exclude_packages.delete_if { |package| found_packages.exclude? package }
+    ohai "Retrieving PyPI dependencies for excluded \"#{exclude_packages.join(" ")}\"..." if !print_only && !silent
+    exclude_packages = pip_report(exclude_packages) + [Package.new(main_package.name)]
 
     new_resource_blocks = ""
     found_packages.sort.each do |package|
@@ -355,16 +348,30 @@ module PyPI
     name.gsub(/[-_.]+/, "-").downcase
   end
 
-  def self.pip_report_to_packages(report, exclude_packages)
+  def self.pip_report(packages)
+    return [] if packages.blank?
+
+    command = [Formula["python"].bin/"python3", "-m", "pip", "install", "-q", "--dry-run",
+               "--ignore-installed", "--report=/dev/stdout", *packages.map(&:to_s)]
+    pip_output = Utils.popen_read({ "PIP_REQUIRE_VIRTUALENV" => "false" }, *command)
+    unless $CHILD_STATUS.success?
+      odie <<~EOS
+        Unable to determine dependencies for "#{packages.join(" ")}" because of a failure when running
+        `#{command.join(" ")}`.
+        Please update the resources manually.
+      EOS
+    end
+    pip_report_to_packages(JSON.parse(pip_output)).uniq
+  end
+
+  def self.pip_report_to_packages(report)
     return [] if report.blank?
 
     report["install"].map do |package|
       name = normalize_python_package(package["metadata"]["name"])
       version = package["metadata"]["version"]
 
-      package = Package.new "#{name}==#{version}"
-
-      package if exclude_packages.exclude? package
+      Package.new "#{name}==#{version}"
     end.compact
   end
 end