diff --git a/Library/Homebrew/extend/ENV.rb b/Library/Homebrew/extend/ENV.rb
index b3b8d26b30..095d05b70e 100644
--- a/Library/Homebrew/extend/ENV.rb
+++ b/Library/Homebrew/extend/ENV.rb
@@ -33,9 +33,11 @@ module HomebrewEnvExtension
       self['CMAKE_PREFIX_PATH'] = "#{HOMEBREW_PREFIX}"
     end
 
-    append 'CPPFLAGS', "-F#{HOMEBREW_PREFIX}/Frameworks"
-    append 'LDFLAGS', "-F#{HOMEBREW_PREFIX}/Frameworks"
-    self['CMAKE_FRAMEWORK_PATH'] = HOMEBREW_PREFIX/"Frameworks"
+    if (HOMEBREW_PREFIX/'Frameworks').exist?
+      append 'CPPFLAGS', "-F#{HOMEBREW_PREFIX}/Frameworks"
+      append 'LDFLAGS', "-F#{HOMEBREW_PREFIX}/Frameworks"
+      self['CMAKE_FRAMEWORK_PATH'] = HOMEBREW_PREFIX/"Frameworks"
+    end
 
     # Os is the default Apple uses for all its stuff so let's trust them
     set_cflags "-Os #{SAFE_CFLAGS_FLAGS}"