diff --git a/Library/Homebrew/requirements/python_dependency.rb b/Library/Homebrew/requirements/python_dependency.rb
index 610bc1c6b9..90bd14fa6b 100644
--- a/Library/Homebrew/requirements/python_dependency.rb
+++ b/Library/Homebrew/requirements/python_dependency.rb
@@ -258,7 +258,6 @@ class PythonInstalled < Requirement
     ENV.prepend 'PATH', binary.dirname, ':' unless from_osx?
 
     ENV['PYTHONHOME'] = nil  # to avoid fuck-ups.
-    ENV['PYTHONNOUSERSITE'] = '1'
     ENV['PYTHONPATH'] = global_site_packages.to_s unless brewed?
     # Python respects the ARCHFLAGS var if set. Shall we set them here?
     # ENV['ARCHFLAGS'] = ??? # FIXME