diff --git a/Library/Homebrew/cleanup.rb b/Library/Homebrew/cleanup.rb
index 605a7e17c9..9bf8bfce36 100644
--- a/Library/Homebrew/cleanup.rb
+++ b/Library/Homebrew/cleanup.rb
@@ -30,6 +30,7 @@ module Homebrew
           glide_home
           java_cache
           npm_cache
+          pip_cache
           gclient_cache
         ].include?(pathname.basename.to_s)
       end
diff --git a/Library/Homebrew/formula.rb b/Library/Homebrew/formula.rb
index 2ab55beccd..f0fc5d6c60 100644
--- a/Library/Homebrew/formula.rb
+++ b/Library/Homebrew/formula.rb
@@ -2871,6 +2871,7 @@ class Formula
       GOCACHE:                 "#{HOMEBREW_CACHE}/go_cache",
       GOPATH:                  "#{HOMEBREW_CACHE}/go_mod_cache",
       CARGO_HOME:              "#{HOMEBREW_CACHE}/cargo_cache",
+      PIP_CACHE_DIR:           "#{HOMEBREW_CACHE}/pip_cache",
       CURL_HOME:               ENV.fetch("CURL_HOME") { Dir.home },
       PYTHONDONTWRITEBYTECODE: "1",
     }