diff --git a/Library/Homebrew/extend/os/linux/install.rb b/Library/Homebrew/extend/os/linux/install.rb
index b4f9cfdc8e..0ea7690616 100644
--- a/Library/Homebrew/extend/os/linux/install.rb
+++ b/Library/Homebrew/extend/os/linux/install.rb
@@ -38,13 +38,13 @@ module Homebrew
     def perform_preinstall_checks(all_fatal: false, cc: nil)
       generic_perform_preinstall_checks(all_fatal: all_fatal, cc: cc)
       symlink_ld_so
-      symlink_gcc_libs
+      setup_preferred_gcc_libs
     end
 
     def global_post_install
       generic_global_post_install
       symlink_ld_so
-      symlink_gcc_libs
+      setup_preferred_gcc_libs
     end
 
     def check_cpu
@@ -77,23 +77,53 @@ module Homebrew
     end
     private_class_method :symlink_ld_so
 
-    def symlink_gcc_libs
+    def setup_preferred_gcc_libs
       gcc_opt_prefix = HOMEBREW_PREFIX/"opt/#{OS::LINUX_PREFERRED_GCC_RUNTIME_FORMULA}"
+      glibc_installed = (HOMEBREW_PREFIX/"opt/glibc/lib/ld-linux-x86-64.so.2").readable?
+
+      return unless gcc_opt_prefix.readable?
+
+      if glibc_installed
+        ld_so_conf_d = HOMEBREW_PREFIX/"etc/ld.so.conf.d"
+        unless ld_so_conf_d.exist?
+          ld_so_conf_d.mkpath
+          FileUtils.chmod "go-w", ld_so_conf_d
+        end
+
+        # Add gcc to ld search paths
+        ld_gcc_conf = ld_so_conf_d/"50-homebrew-preferred-gcc.conf"
+        unless ld_gcc_conf.exist?
+          ld_gcc_conf.atomic_write <<~EOS
+            # This file is generated by Homebrew. Do not modify.
+            #{gcc_opt_prefix}/lib/gcc/#{PREFERRED_GCC_RUNTIME_VERSION}
+          EOS
+          FileUtils.chmod "u=rw,go-wx", ld_gcc_conf
+
+          FileUtils.rm_f HOMEBREW_PREFIX/"etc/ld.so.cache"
+          system HOMEBREW_PREFIX/"opt/glibc/sbin/ldconfig"
+        end
+      else
+        odie "#{HOMEBREW_PREFIX}/lib does not exist!" unless (HOMEBREW_PREFIX/"lib").readable?
+      end
 
       GCC_RUNTIME_LIBS.each do |library|
-        gcc_library = gcc_opt_prefix/"lib/gcc/#{PREFERRED_GCC_RUNTIME_VERSION}/#{library}"
         gcc_library_symlink = HOMEBREW_PREFIX/"lib/#{library}"
-        # Skip if the link target doesn't exist.
-        next unless gcc_library.readable?
 
-        # Also skip if the symlink already exists.
-        next if gcc_library_symlink.readable? && (gcc_library_symlink.readlink == gcc_library)
+        if glibc_installed
+          # Remove legacy symlinks
+          FileUtils.rm gcc_library_symlink if gcc_library_symlink.symlink?
+        else
+          gcc_library = gcc_opt_prefix/"lib/gcc/#{PREFERRED_GCC_RUNTIME_VERSION}/#{library}"
+          # Skip if the link target doesn't exist.
+          next unless gcc_library.readable?
 
-        odie "#{HOMEBREW_PREFIX}/lib does not exist!" unless (HOMEBREW_PREFIX/"lib").readable?
+          # Also skip if the symlink already exists.
+          next if gcc_library_symlink.readable? && (gcc_library_symlink.readlink == gcc_library)
 
-        FileUtils.ln_sf gcc_library, gcc_library_symlink
+          FileUtils.ln_sf gcc_library, gcc_library_symlink
+        end
       end
     end
-    private_class_method :symlink_gcc_libs
+    private_class_method :setup_preferred_gcc_libs
   end
 end